ORGANISATION/COMPANYLuxembourg Institute of Health
RESEARCH FIELDBiological sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE24/12/2020 22:00 - Europe/Brussels
LOCATIONLuxembourg › Strassen
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE31/01/2021
IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?Yes
3-year fixed-term contract (renewable for 1 year), full time. Start date: January/February 2021
Background. Gliomas represent approximately 80% of all malignant tumours of the central nervous system. Among them, Glioblastoma (GBM) is the highest-grade glioma and the most common malignant brain tumour in adults. Despite established standard care of treatment, GBM recurrence is inevitable and prognosis remains poor with a median survival of 15 months after diagnosis. Hence, the development of novel therapeutic options, including immunotherapies, are needed. Importantly, GBM is a highly immunosuppressive cancer, where tumour-associated microglia/macrophages can constitute up to 30-40% of the tumour mass playing a key role in immune escape mechanisms. Thus, targeting these cells is emerging as a promising strategy for immunotherapy.
Objective. We aim to understand the role of tumour-associated microglia/macrophages along GBM progression with the goal to identify new prognostic markers and therapeutic targets.
Training and research environment. The Neuro-Immunology Group belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumour progression using a wide range of cutting edge technologies, including genomics, transcriptomics and proteomics analyses, as well as in vitro and in vivo imaging modalities using both patient cohorts and state-of-the-art animal models for cancer research. The PhD student will be in charge of an Action LIONS funded project that aims to uncover targets to shift immune-suppressed TAMs into reactive cells in Glioblastoma.
Key Skills, Experience and Qualifications
- Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
- Experience in cell culture, transcriptomics (scRNA-seq), confocal microscopy and flow-cytometry techniques.
- Mouse experimentation practice and FELASA diploma (or equivalent) would be considered as an asset.
- Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills, sense of priority and ability to work with others.
- Fluency in English is mandatory.
Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with universities and other research institutes.
Additional information on the group can be found here : https://nig.lih.lu
Applicants should submit a cover letter and a curriculum vitae by December 15, 2020 via our website (www.lih.lu/jobs)
EURAXESS offer ID: 580394
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