24/11/2020
The Human Resources Strategy for Researchers

PhD Student in Immuno-Oncology

This job offer has expired


  • ORGANISATION/COMPANY
    Luxembourg Institute of Health
  • RESEARCH FIELD
    Biological sciences
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    24/12/2020 22:00 - Europe/Brussels
  • LOCATION
    Luxembourg › Strassen
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    31/01/2021
  • IS THE JOB RELATED TO STAFF POSITION WITHIN A RESEARCH INFRASTRUCTURE?
    Yes

OFFER DESCRIPTION

3-year fixed-term contract (renewable for 1 year), full time. Start date: January/February 2021

Background. Gliomas represent approximately 80% of all malignant tumours of the central nervous system. Among them, Glioblastoma (GBM) is the highest-grade glioma and the most common malignant brain tumour in adults. Despite established standard care of treatment, GBM recurrence is inevitable and prognosis remains poor with a median survival of 15 months after diagnosis. Hence, the development of novel therapeutic options, including immunotherapies, are needed. Importantly, GBM is a highly immunosuppressive cancer, where tumour-associated microglia/macrophages can constitute up to 30-40% of the tumour mass playing a key role in immune escape mechanisms. Thus, targeting these cells is emerging as a promising strategy for immunotherapy.

Objective. We aim to understand the role of tumour-associated microglia/macrophages along GBM progression with the goal to identify new prognostic markers and therapeutic targets.

Training and research environment. The Neuro-Immunology Group belongs to the Department of Oncology, whose research activities focus on the cellular and molecular mechanisms of tumour progression using a wide range of cutting edge technologies, including genomics, transcriptomics and proteomics analyses, as well as in vitro and in vivo imaging modalities using both patient cohorts and state-of-the-art animal models for cancer research. The PhD student will be in charge of an Action LIONS funded project that aims to uncover targets to shift immune-suppressed TAMs into reactive cells in Glioblastoma.

 

Key Skills, Experience and Qualifications

  • Master’s degree in Biomedical Sciences or Immunology. Prior experience in cancer research would be an advantage, but is not mandatory.
  • Experience in cell culture, transcriptomics (scRNA-seq), confocal microscopy and flow-cytometry techniques.
  • Mouse experimentation practice and FELASA diploma (or equivalent) would be considered as an asset.
  • Excellent time management, rigour, perseverance, scientific creativity and originality, writing skills, sense of priority and ability to work with others.
  • Fluency in English is mandatory.

Researchers are supported by easy access to scientific expertise, well-equipped facilities, an active seminar program as well as the possibility for close collaborations with universities and other research institutes.

Additional information on the group can be found here : https://nig.lih.lu

Applicants should submit a cover letter and a curriculum vitae by December 15, 2020 via our website (www.lih.lu/jobs)

More Information

Work location(s)
1 position(s) available at
Luxembourg Institute of Health
Luxembourg
Strassen
1445
1A-B, rue Thomas EdisonL-1445 StrassenLuxembourg

EURAXESS offer ID: 580394

Disclaimer:

The responsibility for the jobs published on this website, including the job description, lies entirely with the publishing institutions. The application is handled uniquely by the employer, who is also fully responsible for the recruitment and selection processes.

 

Please contact support@euraxess.org if you wish to download all jobs in XML.